What question did this study set out to answer?

This research aims to explore the effects of dietary L-glutamine on kidney function and the renal proteome in humanized sickle cell mice with preserved kidney function.

May 14, 2026Physiology

Kidney function and renal proteomic responses to dietary L-glutamine supplementation in humanized sickle cell mice

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Authors

OAOlufunke ArisheUniversity of Missouri Health System OFOlufunke FalayiUniversity of Missouri AAAyodeji AdepojuUniversity of Missouri

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Implication

Randomized trial investigates kidney function outcomes in sickle cell mice following L-glutamine supplementation, suggesting metabolic activity without renal improvement.

Key Points

This research aims to explore the effects of dietary L-glutamine on kidney function and the renal proteome in humanized sickle cell mice with preserved kidney function.
HbAA and HbSS mice (12-16 weeks) were randomized for 10 weeks to a control diet or a diet supplemented with L-glutamine (200 g/3987 kcal).
Plasma creatinine, BUN, proteinuria, oxidative stress markers, and proteomic analyses were performed at necropsy.
L-glutamine did not improve plasma creatinine, BUN, or oxidative stress markers in either genotype.
Proteomics revealed substantial changes in the kidney proteome of both genotypes under L-glutamine diet, with 203 proteins altered in HbSS and 216 in HbAA mice.
Overall, L-glutamine showed no functional renal improvement in HbSS mice despite inducing significant metabolic changes.

Cite This Study

Arishe et al. (2026) studied this question.

synapsesocial.com/papers/6a05677ca550a87e60a1f82e https://doi.org/10.1152/physiol.2026.41.s1.2300794

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Implication

Randomized trial investigates kidney function outcomes in sickle cell mice following L-glutamine supplementation, suggesting metabolic activity without renal improvement.

Kidney function and renal proteomic responses to dietary L-glutamine supplementation in humanized sickle cell mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Kidney function and renal proteomic responses to dietary L-glutamine supplementation in humanized sickle cell mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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