What question did this study set out to answer?

To explore the differences in autonomic and behavioral thermoregulation between synthetic torpor and fasting-induced torpor in mice.

May 14, 2026Physiology

A tail of two torpors: insight from autonomic and behavioural thermoregulation

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Randomized trial investigates thermoregulation during synthetic and fasting-induced torpor in mice, suggesting intact thermoregulatory function.

To explore the differences in autonomic and behavioral thermoregulation between synthetic torpor and fasting-induced torpor in mice.
Investigated autonomic thermoregulation using POA neurons activated via DREADDs.
Recorded tail temperature during entry into fasting-induced and synthetic torpor.
Measured thermal preference using a thermal ramp during synthetic torpor.
Synthetic torpor lowered core temperature by -3.35°C (p=0.0023).
Tail temperature rose during synthetic torpor compared to fasting-induced torpor (p=0.004).
CNO injection resulted in a significant preference for warmer environments in POA torpor-TRAP mice (p=0.0094).

Wheatley et al. (2026) studied this question.

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Randomized trial investigates thermoregulation during synthetic and fasting-induced torpor in mice, suggesting intact thermoregulatory function.