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May 14, 2026Physiology

Localization of the V-ATPase-interacting protein, TBC1D24, in rodent kidney

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Authors

AEAmity EatonMMMaria MerkulovaDBD F Brown

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Overview

Randomized trial investigates TBC1D24 localization in rodent kidneys, highlighting potential roles in kidney and neurological disorders.

Key Points

  • This research aims to explore the localization of TBC1D24 in rodent kidneys and its implications for cellular function and disease.
  • Developed a novel rabbit polyclonal antibody against TBC1D24 for localization studies.
  • Performed western blotting and indirect immunofluorescence in rat kidney tissues.
  • Examined subcellular localization in various kidney segments, focusing on intercalated cells (ICs).
  • TBC1D24 was primarily localized in A-IC of the inner medullary collecting ducts, with diffuse staining in adjacent principal cells.
  • Minimal TBC1D24 was found in V-ATPase-rich microvilli, suggesting involvement in the reversible assembly of the V-ATPase holoenzyme.
  • TBC1D24 expression varied across kidney segments, notably enriched in B-type IC in the cortex.

Cite This Study

Eaton et al. (2026) studied this question.

synapsesocial.com/papers/6a056795a550a87e60a1fb4chttps://doi.org/10.1152/physiol.2026.41.s1.2300668
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