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May 14, 2026Academia Neuroscience and Brain ResearchOpen Access

Mitochondrial DNA and neurofilament release as Parkinson’s phenotypes in midbrain organoids

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Authors

SSSònia Sabaté‐SolerIRIsabel RosetyGGGemma Gomez‐Giro

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Overview

Randomized trial evaluates mitochondrial DNA and neurofilament levels in midbrain organoids, suggesting their potential as biomarkers.

Key Points

  • This research investigates the use of midbrain organoids to identify extracellular biomarkers associated with Parkinson's disease.
  • Utilized cell culture supernatant from organoids for measuring neurofilament light chain levels via ELISA.
  • Examined mitochondrial DNA phenotypes through digital PCR.
  • Conducted immunofluorescence staining to quantify alpha-synuclein and GFAP levels.
  • PD patient-specific organoids released higher levels of neurofilament light chain and mitochondrial DNA.
  • Immunofluorescence showed elevated phosphorylated alpha-synuclein and GFAP levels in patient organoids.

Cite This Study

Sabaté‐Soler et al. (2026) studied this question.

synapsesocial.com/papers/6a0567a8a550a87e60a1fd31https://doi.org/10.20935/acadneurosci8295
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