Herbal Liposomal Gel of Centella Asiatica Extract for Scar Reduction and Skin Regeneration

Herbal liposomal gel formulations of Centella asiatica leaf extract were developed and evaluated for their potential in scar reduction and skin regeneration. The ethanolic extract of C. asiatica yielded a higher percentage (2.72%) of bioactive compounds compared to petroleum ether, and phytochemical analysis confirmed the presence of alkaloids, flavonoids, glycosides, phenolics, and triterpenoids, which are known to enhance wound healing and collagen synthesis. Liposomes were prepared and characterized, with formulation F3 exhibiting the smallest particle size (185.93 nm) and highest negative zeta potential (−31.8 mV), indicating optimal stability and skin penetration potential. The gel formulation displayed desirable physical properties, including smooth semi-solid consistency, off-white color, uniform homogeneity, pH 6.8, appropriate viscosity (4149 cps), and good spreadability (10.17 gm·cm/sec). Stability studies over 90 days showed minimal changes in pH and viscosity, demonstrating the robustness of the formulation. Overall, the C. asiatica liposomal gel represents a stable, effective, and biocompatible system with promising potential for topical application in scar management and skin regeneration.