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The aim is to synthesize stable N7-dG catechol and estrone adducts to understand their role in mutagenesis.

May 14, 2026MoleculesOpen Access

Synthesis and Characterization of Chemically Stable N7-dG Estrone and Catechol Adducts

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The aim is to synthesize stable N7-dG catechol and estrone adducts to understand their role in mutagenesis.
Synthesized N7-dG adducts using 2′-fluorinated deoxyguanosine to inhibit depurination.
Utilized ROESY 2D NMR spectroscopy for structural analysis.
Conducted molecular modeling to assess conformation in solution.
Stable N7-dG adducts were successfully synthesized, revealing consistent through-space correlations.
Structural analysis suggested that these aryl adducts preserve Watson-Crick base pairing while promoting tautomerization.
Findings indicate a new potential mechanism for estrogen-induced mutations that does not involve depurination.

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Randomized trial synthesizes stable N7-dG adducts in vitro, suggesting new mechanisms of estrogen-induced mutagenesis.

Baily et al. (2026) studied this question.

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