Association between triglyceride-glucose-atherogenic index of plasma and cardiovascular disease in middle-aged and older Chinese and American individuals: A cross-sectional analysis of two nationwide cohort datasets.

The relationship between the triglyceride-glucose (TyG) index combined with the atherogenic index of plasma (AIP) and cardiovascular disease (CVD) remains unclear in both Chinese and American populations. This analytic cross-sectional study used data from two nationwide datasets: 10,342 participants from the China Health and Retirement Longitudinal Study and 4185 from the National Health and Nutrition Examination Survey. Multivariable logistic regression, restricted cubic spline analysis, and receiver operating characteristic curve analysis were used to investigate the relationship between TyG, AIP, TyG-AIP, and CVD. The results showed a significant positive association between high levels of TyG index, AIP, and TyG-AIP with the risk of CVD. The estimates were 1.66 (95% CI: 1.41-1.95) and 1.84 (95% CI: 1.43-2.37) for TyG index, 1.69 (95% CI: 1.43-1.99) and 1.97 (95% CI: 1.53-2.54) for AIP, and 1.68 (95% CI: 1.43-1.98) and 1.97 (95% CI: 1.53-2.54) for TyG-AIP in China health and retirement longitudinal study and National Health and Nutrition Examination Survey, respectively. Restricted cubic spline analyses showed that most of the above relationships were linear (P-overall < .001, P-nonlinear > .05). Receiver operating characteristic analysis showed that TyG-AIP had better discriminatory ability for CVD than TyG or AIP alone. The study demonstrated linear associations between higher TyG index, AIP, and TyG-AIP levels and increased CVD risk in middle-aged and older populations. Of the indicators evaluated, TyG-AIP showed the greatest ability to distinguish individuals with CVD.