Formulation And Evaluation of Polyherbal Oral Disintegrating Tablet for The Treatment of Hypertension: A Comprehensive Review

Hypertension is a chronic cardiovascular disorder characterized by elevated blood pressure and is considered one of the leading causes of mortality worldwide. Conventional antihypertensive drugs are effective but are often associated with adverse effects such as dizziness, fatigue, electrolyte imbalance, and poor patient compliance. Herbal medicines have gained increasing attention due to their natural origin, safety, and therapeutic efficacy. The present review focuses on the formulation and evaluation of polyherbal oral disintegrating tablets (ODTs) using Terminalia arjuna bark and Withania somnifera root for the management of hypertension. Terminalia arjuna possesses cardioprotective, antioxidant, anti-inflammatory, and antihypertensive properties, while Withania somnifera exhibits adaptogenic, anti-stress, and cardiotonic activities. Oral disintegrating tablets are advantageous because they disintegrate rapidly in saliva without water, improving patient compliance, especially in geriatric patients. This review discusses hypertension, herbal management, phytochemistry, formulation methods, evaluation parameters, mechanisms of action, and future prospects of polyherbal ODTs.