Key result
Polyherbal formulations lower blood pressure via synergistic vasodilation, diuresis, and RAAS inhibition.
Why the study?
Long-term use of synthetic antihypertensive drugs is often associated with adverse effects and poor patient compliance, prompting interest in herbal and polyherbal therapies as alternatives for hypertension management.
Do polyherbal formulations (comprising medicinal plants such as Terminalia arjuna, Tribulus terrestris, Allium sativum, and Moringa oleifera) reduce blood pressure through synergistic mechanisms in patients with hypertension?
Do polyherbal formulations (comprising medicinal plants such as Terminalia arjuna, Tribulus terrestris, Allium sativum, and Moringa oleifera) reduce blood pressure through synergistic mechanisms in patients with hypertension?
This narrative review highlights the potential of polyherbal formulations (combining Terminalia arjuna, Tribulus terrestris, Allium sativum, and Moringa oleifera) to manage hypertension via multi-target synergistic mechanisms, while emphasizing the critical need for standardization and large-scale clinical validation.
High blood pressure is a significant health issue worldwide and a primary risk factor for cardiovascular conditions like stroke, heart attack, and heart failure. Despite the availability of various synthetic antihypertensive drugs, their long-term use is often associated with adverse effects and poor patient compliance. This has led to growing interest in herbal and polyherbal therapies as safer and more effective alternatives. Polyherbal formulations, comprising multiple medicinal plants, can improve therapeutic effects through synergistic interactions.This review examines the antihypertensive properties of medicinal plants such as Terminalia arjuna, Tribulus terrestris, Allium sativum, and Moringa oleifera. These plants contain bioactive phytochemicals such as flavonoids, saponins, tannins, alkaloids, and organosulfur compounds that help lower blood pressure through mechanisms including vasodilation, antioxidant effects, diuretic activity, and inhibition of the renin-angiotensin-aldosterone system.Synergism in polyherbal formulations enables a multi-target approach, improving efficacy while reducing toxicity. Although promising, polyherbal formulations still face challenges, including a lack of standardization and limited clinical evidence. Further research and clinical validation are essential to establish polyherbal formulations as effective therapeutic options for hypertension management.
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Gupta et al. (2026) conducted a review in Hypertension. Polyherbal formulations (Terminalia arjuna, Tribulus terrestris, Allium sativum, and Moringa oleifera) vs. Single-drug or conventional synthetic antihypertensive therapy was evaluated on Blood pressure reduction and antihypertensive mechanisms. Polyherbal formulations of Terminalia arjuna, Tribulus terrestris, Allium sativum, and Moringa oleifera lower blood pressure via synergistic vasodilation, diuresis, and RAAS inhibition.
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