December 27, 2019Endocrine Metabolic & Immune Disorders - Drug Targets

Medicinal plant derivatives, including garlic, celery, black cumin, and ginseng, demonstrated efficiency in lowering blood pressure through direct vasorelaxant effects or indirect mechanisms like ACE or RAS inhibition.

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Why the study?

Hypertension is a major global risk factor, and medicinal plants are widely used for its management, prompting a critical review of published experimental and clinical investigations from the last decade.

Do medicinal plant derivatives lower blood pressure in experimental and clinical settings?

Design

Review of experimental and clinical studies

Authors

MAMohammed Ajebli MEMohamed Eddouks

Discussion

Member takes

Overview

Herbal therapies may aid hypertension management; leaves open need for rigorous RCTs before practice change.

Structured PICO

Do medicinal plant derivatives lower blood pressure in experimental and clinical settings?

Population

Experimental models and clinical populations with hypertension

Intervention

Herbal therapies, medicinal plants, and their derivatives (e.g., garlic, celery, Black Cumin, Ginseng, allicin, apigenin)

Outcome

Blood pressure lowering abilitiessurrogate

While medicinal plant derivatives show potential for lowering blood pressure via various mechanisms, significant gaps remain in standardization, mechanistic understanding, and clinical efficacy/safety data.

Limitations

lack of standardization at the level of experimental study methods
need to study purified molecules
mechanistic studies remain partial
few advanced clinical studies have been conducted
determination of the efficacy/safety ratio remains absent

Cite This Study

Ajebli et al. (2019) studied this question.

synapsesocial.com/papers/6a7148ac8031ec7bb1dcdf8b https://doi.org/10.2174/1871530320666191227104648

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December 27, 2019Endocrine Metabolic & Immune Disorders - Drug Targets

Medicinal plant derivatives, including garlic, celery, black cumin, and ginseng, demonstrated efficiency in lowering blood pressure through direct vasorelaxant effects or indirect mechanisms like ACE or RAS inhibition.

View Full Paper

Ask AI

Bookmark

Why the study?

Do medicinal plant derivatives lower blood pressure in experimental and clinical settings?

Design

Review of experimental and clinical studies

Authors

MAMohammed Ajebli MEMohamed Eddouks

Discussion

Member takes

Overview

Herbal therapies may aid hypertension management; leaves open need for rigorous RCTs before practice change.

Structured PICO

Do medicinal plant derivatives lower blood pressure in experimental and clinical settings?

Population

Experimental models and clinical populations with hypertension

Intervention

Herbal therapies, medicinal plants, and their derivatives (e.g., garlic, celery, Black Cumin, Ginseng, allicin, apigenin)

Outcome

Blood pressure lowering abilitiessurrogate

Limitations

lack of standardization at the level of experimental study methods
need to study purified molecules
mechanistic studies remain partial
few advanced clinical studies have been conducted
determination of the efficacy/safety ratio remains absent

Cite This Study

Ajebli et al. (2019) studied this question.

synapsesocial.com/papers/6a7148ac8031ec7bb1dcdf8b https://doi.org/10.2174/1871530320666191227104648

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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