PulseExploreJournal ClubTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 14, 2026European Heart Journal Acute Cardiovascular Care

Study of variables in the stratification of risk in acute myocarditis: results from a tertiary hospital cohort

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Acute myocarditis has heterogeneous presentations and varying risk levels; this study evaluated parameters to improve initial risk stratification for identifying patients at higher risk of worse outcomes.

What clinical, analytical, and echocardiographic parameters differentiate high-risk from intermediate-risk acute myocarditis?

Population

19 patients admitted to a tertiary hospital Cardiac Intensive Care Unit with intermediate or high-risk myocarditis

Comparison

Intermediate-risk vs high-risk myocarditis

Design

Descriptive historic cohort study

Key result

High-risk acute myocarditis was associated with a significantly later peak in troponin levels (median 3 days vs 0 days), higher shock index, microvoltages, LV oedema, and RV dysfunction.

Authors

IOI Cucurull OrtegaMSM Rodiriguez De Rivera SocorroJVJ E Lujan Valencia

Discussion

Loading...

Member takes

Overview

Delayed troponin peak and LVEF 12.5% mark higher-risk acute myocarditis; leaves open prospective validation for early stratification.

Key Points

  • To evaluate parameters for better risk stratification in patients with acute myocarditis.
  • Descriptive study of a cohort of 19 patients in a tertiary hospital's Cardiac Intensive Care Unit.
  • Comparison of clinical, analytical, and echocardiographic variables using statistical tests like Fisher exact test, chi squared test, or Mann-Whitney U test.
  • Analysis of troponin kinetic (TnIUs) among risk groups.
  • High-risk patients were predominantly female and displayed higher shock index upon admission.
  • C-reactive protein and procalcitonin were significantly elevated in the high-risk group.
  • Troponin levels peaked significantly later in high-risk patients compared to intermediate-risk patients.

Study Design

Type

Cohort (n=19)

Multicenter

No

Structured PICO

What clinical, analytical, and echocardiographic parameters differentiate high-risk from intermediate-risk acute myocarditis?

P
Population
19 patients admitted to the Cardiac Intensive Care Unit of a tertiary hospital in Spain with the diagnosis of intermediate or high-risk myocarditis (according to the 2025 ESC Guidelines for the management of myocarditis and pericarditis) between January 2023 and March 2025.
O
Outcome
Differences in clinical, analytical, and echocardiographic variables between intermediate and high-risk myocarditis groupssurrogate

Shock index, EKG microvoltages, LV oedema, RV dysfunction, and delayed troponin peak may serve as useful parameters to identify patients with high-risk acute myocarditis.

Limitations

  • Insufficient statistical power
  • insufficient statistical power

Cite This Study

Ortega et al. (2026) conducted a cohort in Acute myocarditis (n=19). High-risk myocarditis vs. Intermediate-risk myocarditis was evaluated on Differences in clinical, analytical and echocardiographic variables. High-risk acute myocarditis was associated with a significantly later peak in troponin levels (median 3 days vs 0 days), higher shock index, microvoltages, LV oedema, and RV dysfunction.

synapsesocial.com/papers/6a0567fda550a87e60a2039ahttps://doi.org/10.1093/ehjacc/zuag046.228
View Full Paper
Ask AI
Bookmark
Share