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The review aims to explore the impact of protein modifications and the protein quality control system on Alzheimer’s disease pathology.

Protein Modifications and Quality Control System: Target for Alzheimer’s Disease Therapy

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The review aims to explore the impact of protein modifications and the protein quality control system on Alzheimer’s disease pathology.
Analyzed the roles of post-translational modifications (PTMs) such as phosphorylation and ubiquitination on amyloid-β and tau behavior.
Discussed the implications of impaired protein quality control in Alzheimer’s disease progression.
Identified dysregulation of PTMs and protein quality control as key mechanisms in Alzheimer's disease.
Proposed that targeting these pathways may lead to more effective therapies compared to solely reducing amyloid-β.

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Review describes how protein modifications and quality control influence Alzheimer’s disease, suggesting new treatment strategies.

Sheikh et al. (2026) studied this question.

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