ABSTRACT Sulfoxides are robust and versatile precursors in organic synthesis, enabling the construction of complex architectures. The venerable interrupted Pummerer reaction, which employs simple and stable sulfoxides as substrates, provides a powerful strategy for sulfenyl group installation and late‐stage functionalization. This review summarizes representative advances from the past decade, encompassing C─H sulfenylation, electrophilic cyclization, interrupted Pummerer/sigmatropic rearrangement cascades, interrupted Pummerer‐mediated cross‐couplings, interrupted Pummerer‐mediated glycosylations, and related transformations. Given the numerous merits of this chemistry, many more exciting discoveries and developments can be anticipated in the future.
Xing et al. (Fri,) studied this question.