pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes

Yizhi Wu; Peipei Xu; Jing Lin; Wanjing Li; Qing Lin; Hanhao Lu; Jingbo Chen; Zhenhua Liu; Yudong Lu

doi:10.1039/d6ra00194g

January 1, 2026RSC AdvancesOpen Access

pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes

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Key Points

This research aims to develop a pH-responsive hydrogel system for targeted delivery of 5-fluorouracil.
Utilized a composite hydrogel bead system with a dual-locking mechanism for drug delivery.
Achieved a drug loading capacity of 81.23%.
Evaluated release kinetics showcasing ultra-low release rates.
Demonstrated a release rate of less than 4% for the drug.
Achieved colon-targeted delivery using pH-trigger mechanism.

Implication

Demonstrates precise colon-targeted drug delivery using pH-responsive hydrogel beads, implying improved treatment efficacy.

Abstract

A pH-responsive hydrogel bead system with a dual-locking mechanism (pH-triggered matrix disintegration and host–guest complex dissociation) achieves high loading (81.23%) and ultra-low release (<4%) for precise colon-targeted 5-FU delivery.

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a05680ea550a87e60a20600 https://doi.org/10.1039/d6ra00194g

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pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes

Key Points

Implication

Abstract

Discussion

Cite This Study

pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes

Key Points

Implication

Abstract

Discussion

Cite This Study

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