pH-responsive sodium alginate/CMCS/CMCNa composite hydrogel beads for sustained delivery of 5-fluorouracil-β-cyclodextrin inclusion complexes

Key Points

• This research aims to develop a pH-responsive hydrogel system for targeted delivery of 5-fluorouracil.
• Utilized a composite hydrogel bead system with a dual-locking mechanism for drug delivery.
• Achieved a drug loading capacity of 81.23%.
• Evaluated release kinetics showcasing ultra-low release rates.
• Demonstrated a release rate of less than 4% for the drug.
• Achieved colon-targeted delivery using pH-trigger mechanism.