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This research investigates the role of selenocyanate in neuroprotection and redox homeostasis related to epilepsy.

May 14, 2026Analytical Chemistry1 citations

A Brain-Permeable Selenocyanate Near-Infrared (NIR) Probe Platform for H 2 S Dynamics Imaging: Insights into Redox Homeostasis and Antiepileptic Therapy

LLLe LiuWuhan National Laboratory for Optoelectronics JZJie ZhangWuhan National Laboratory for Optoelectronics DHDeming HeWuhan National Laboratory for Optoelectronics

Key Points

This research investigates the role of selenocyanate in neuroprotection and redox homeostasis related to epilepsy.
Utilized a brain-permeable selenocyanate NIR probe platform for imaging H2S dynamics.
Developed in-vivo biosensors based on a cyclization strategy for therapeutic monitoring.
Analyzed redox homeostasis in the context of antiepileptic therapy.
Demonstrated effective imaging of H2S dynamics within the brain.
Established the significance of redox homeostasis in neuroprotection during epilepsy.
Supported the development of advanced biosensors for broader biomedical applications.

Abstract

S-mediated neuroprotection and redox homeostasis in epilepsy. Beyond this, the established selenocyanate cyclization strategy provides a versatile and robust chemical platform for the development of next-generation in-vivo biosensors with broad applicability in biomedical research and therapeutic monitoring.

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