Droplet microfluidics: Enabling the tailored fabrication of hydrogel particles

Hydrogel particles are attracting increasing interest as tunable microscale platforms that combine precise architectures with diverse chemical, biological, and physical functionalities. Among fabrication strategies, droplet microfluidics has emerged as a powerful technology for producing monodisperse hydrogel particles with controllable size, composition, and internal structure via precise regulation of microscale fluid dynamics. This review first outlines the fundamental principles of droplet microfluidics, including chip fabrication, channel design, droplet generation dynamics, energy input modes, and fluidic compositions, which collectively underpin reliable particle production. We then highlight compatible hydrogel precursor systems, gelation methods, and functionalization strategies for engineering tailored hydrogel particles. The versatility of such particles is further emphasized, supporting applications in cell culture, 3D bioprinting, drug delivery, and diagnostics. Finally, we provide an outlook on future directions, including system parallelization, process automation, and artificial intelligence integration, anticipated to expand the scalability, functionality, and multidisciplinary impact of droplet‐microfluidic hydrogel platforms.