Key result
MINOCA had comparable 3-year rates of major adverse cardiac and cerebrovascular events compared to MIOCA (23.7% vs. 20.9%; p=0.125) in Korean patients with acute myocardial infarction.
Why the study?
MINOCA is relatively common in East Asian populations, but its clinical characteristics and long-term outcomes have not been fully elucidated in Korea.
Does MINOCA compared to MIOCA affect the risk of long-term MACCE in Korean patients with acute myocardial infarction?
Cohort (n=13,104)
Yes
Does MINOCA compared to MIOCA affect the risk of long-term MACCE in Korean patients with acute myocardial infarction?
In a Korean registry of acute myocardial infarction, patients with MINOCA had comparable 3-year MACCE rates to those with MIOCA, despite differing clinical profiles.
Background Acute myocardial infarction with non-obstructive coronary arteries (MINOCA), including coronary vasospasm, is relatively common in East Asian populations compared with Western countries. However, the clinical characteristics and long-term outcomes of MINOCA have not been fully elucidated in Korea. Purpose To evaluate the clinical characteristics and long-term outcomes of MINOCA in Korean patients with acute myocardial infarction. Methods We analyzed 13,104 patients enrolled in the Korean Acute Myocardial Infarction Registry – National Institutes of Health (KAMIR–NIH) database. Patients were categorized into two groups according to the presence of obstructive coronary lesions: MINOCA and myocardial infarction with obstructive coronary arteries (MIOCA). The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of all-cause death, nonfatal MI, repeat revascularization including percutaneous coronary intervention or coronary artery bypass grafting, cerebrovascular stroke, and rehospitalization within 3 years. Results Among all patients, the proportion of MINOCA was 4.6% (n=598). Patients with MINOCA were more likely to be female. The prevalence of previous MI, non–ST-segment elevation MI (NSTEMI), premature MI, and higher hemoglobin and estimated glomerular filtration rate (eGFR) levels were significantly greater in the MINOCA group. In multivariable logistic regression analysis, female sex (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.40–2.17; p<0.001), previous MI (OR 1.80, 95% CI 1.35–2.41; p<0.001), NSTEMI presentation (OR 6.21, 95% CI 4.85–7.95; p<0.001), and premature MI (OR 1.52, 95% CI 1.13–2.05; p=0.005) were independently associated with MINOCA after adjusting for confounders. On Kaplan–Meier analysis, there was no significant difference in 3-year MACCE between MINOCA and MIOCA groups (23.7% vs. 20.9%; log-rank p=0.125). Conclusions MINOCA is more common in female and premature MI patients. However, long-term clinical outcomes are comparable between MINOCA and MIOCA in the Korean population.
No takes yet. Share an insight, caveat, or question.
Lee et al. (2026) conducted a cohort in Acute myocardial infarction (n=13,104). MINOCA (Myocardial infarction with non-obstructive coronary arteries) vs. MIOCA (Myocardial infarction with obstructive coronary arteries) was evaluated on Major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of all-cause death, nonfatal MI, repeat revascularization, cerebrovascular stroke, and rehospitalization within 3 years (p=0.125). MINOCA had comparable 3-year rates of major adverse cardiac and cerebrovascular events compared to MIOCA (23.7% vs. 20.9%; p=0.125) in Korean patients with acute myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: