Key result
Menstrual hormonal fluctuations linked to SCAD presenting as NSTEMI in a 33-year-old hypertensive woman.
Why the study?
SCAD primarily affects younger women and hormonal fluctuations during menstruation are postulated to trigger transient alterations in vascular wall integrity, highlighting the need for clinical suspicion.
Case Report (n=1)
This case highlights the need for clinical suspicion of SCAD in young women presenting with chest pain, particularly with hypertension and potential menstrual hormonal triggers.
Answers are grounded in this paper and cite their sources.
May heighten SCAD suspicion in young hypertensive women with NSTEMI during menses; hypothesis-generating for hormonal triggers.
Spontaneous coronary artery dissection (SCAD) is an uncommon, non-atherosclerotic cause of acute coronary syndrome (ACS) that primarily affects younger women. We describe the case of a 33-year-old woman with hypertension who presented with acute chest pain during menstruation and was diagnosed with SCAD by coronary angiography. Hormonal fluctuations during the menstrual cycle have been postulated to contribute to the pathogenesis of SCAD through transient alterations in vascular wall integrity and arterial stability in susceptible individuals. This report highlights the need for heightened clinical suspicion of SCAD in young women presenting with chest pain, particularly in the presence of hypertension and potential hormonal triggers.
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Khati et al. (2026) conducted a case report in Spontaneous coronary artery dissection (SCAD) (n=1). Menstrual hormonal fluctuations were identified as a potential trigger for spontaneous coronary artery dissection presenting as NSTEMI in a 33-year-old hypertensive woman.
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