Protonic Capacitor Neural Cell Energetics: Transmembrane-Electrostatically Localized Protons/Cations

The transmembrane-electrostatically localized protons/cations charges (TELPs/TELCs) theory can serve as a theoretical framework to better explain cell electrophysiology and elucidate bioenergetic systems including both delocalized and localized protonic coupling. According to the TELCs model, the excess positive charges of TELCs at one side of the membrane are balanced by the excess negative charges of transmembrane-electrostatically localized hydroxides anions (TELAs) at the other side of the membrane. Application of the TELCs model to neural cells has recently resulted in novel neural transmembrane potential integral equations. In this presentation, we will visit the TELCs-membrane-TELAs model and its applications including its features and predictions that may help better understand neural cell energetics. The TELCs model can be well predictive and provide new opportunities as a theoretical tool for further research to better understand cell physiology, bioenergetics, and neuroscience. This presentation timely provides the latest discoveries, breakthrough advances with new developments and knowledge, directions and opportunities for future research in a major emerging and exciting scientific area of protonic capacitor neural cell energetics: transmembrane-electrostatically localized protons/cations. This abstract was presented at the American Physiology Summit 2026 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.