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February 14, 2015Pacing and Clinical ElectrophysiologyOpen Access

A Model of Electrostimulation Based on the Membrane Capacitance as Electromechanical Transducer for Pore Gating

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Key result

A novel model of electrostimulation based on membrane capacitance as an electromechanical transducer demonstrates that voltage-pulse-content is a linear function of pulse duration at threshold level.

Population

Cellular level model of electrostimulation

Comparison

Model assuming membrane capacitance is an… vs Conventional models assuming stimulation pulse…

Design

Preclinical

Authors

WIW. IrnichMKMark W. Kroll

Discussion

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Member takes

Overview

May inform pacing device optimization; leaves open clinical translation from this animal model.

Structured PICO

P
Population
Cellular level model of electrostimulation
I
Intervention
Model assuming membrane capacitance is an electromechanical transducer compressed by endogenous electric field, released by exogenous field
C
Comparator
Conventional models assuming stimulation pulse charges passive cell membrane capacitance
O
Outcome
Mathematical formulations describing characteristic features of electrostimulation

A novel electromechanical transducer model of electrostimulation provides mathematical formulations that explain cellular excitation, with potential applications in cardiac pacing and defibrillation.

Cite This Study

Irnich et al. (2015) studied Electrostimulation. Electromechanical transducer model of electrostimulation vs. Conventional strength-duration macromodels was evaluated on Voltage-pulse-content as a function of pulse duration. A novel model of electrostimulation based on membrane capacitance as an electromechanical transducer demonstrates that voltage-pulse-content is a linear function of pulse duration at threshold level.

synapsesocial.com/papers/6a9d7a93bbd60fd57f67f251https://doi.org/10.1111/pace.12573
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrical stimulation of cardiac tissue: a bidomain model with active membrane properties1994 · 112 citations
  2. 2A model study of extracellular stimulation of cardiac cells1993 · 41 citations
  3. 3Review of Mechanisms by Which Electrical Stimulation Alters the Transmembrane Potential1999 · 42 citations
  4. 4Effects of Electroporation on the Transmembrane Potential Distribution in a Two‐Dimensional Bidomain Model of Cardiac Tissue1999 · 43 citations
  5. 5Equivalent Circuit Model to Simulate the Neuromuscular Electrical Stimulation2012