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May 1, 1999Journal of Cardiovascular Electrophysiology

Effects of Electroporation on the Transmembrane Potential Distribution in a Two‐Dimensional Bidomain Model of Cardiac Tissue

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Population

Two-dimensional rectangular sheet of cardiac muscle modeled as a bidomain with unequal anisotropy ratios

Design

Preclinical

Authors

FAFelipe AguelKDKATHERINE A. DEBRUTNWKWanda Krassowska

Discussion

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Overview

Current thresholds may refine defibrillation models; leaves open validation for clinical shock design.

Structured PICO

P
Population
Two-dimensional rectangular sheet of cardiac muscle modeled as a bidomain with unequal anisotropy ratios
I
Intervention
Stimulating current (Io) of 0.05-20 A/m delivered through a pair of electrodes
O
Outcome
Transmembrane potential (Vm) distributionsurrogate

Electroporation of the cardiac membrane plays an important role in the distribution of transmembrane potential induced by defibrillation strength shocks.

Cite This Study

Aguel et al. (1999) studied this question.

synapsesocial.com/papers/6a754b53f5fc3941440355e6https://doi.org/10.1111/j.1540-8167.1999.tb00247.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transmembrane potential changes caused by shocks in guinea pig papillary muscle1996 · 49 citations
  2. 2Acute voltage, charge, and energy thresholds as functions of electrode size for electrical stimulation of the canine heart1979 · 28 citations
  3. 3Comparison of the defibrillation threshold and the upper limit of ventricular vulnerability.1986 · 250 citations
  4. 4Nonuniform Muscle Fiber Orientation Causes Spiral Wave Drift in a Finite Element Model of Cardiac Action Potential Propagation1994 · 54 citations
  5. 5Effects of Electroporation on Transmembrane Potential Induced by Defibrillation Shocks1995 · 72 citations