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March 1, 1994IEEE Transactions on Biomedical Engineering

Electrical stimulation of cardiac tissue: a bidomain model with active membrane properties

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Population

Bidomain model of cardiac tissue with active membrane properties (numerical calculations)

Design

Preclinical

Authors

BRBradley J. RothCleveland ClinicJWJohn P. WikswoElectrophysiology

Discussion

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Implication

Supports refined bidomain models for cardiac stimulation; leaves open clinical translation to arrhythmia device therapy.

Structured PICO

P
Population
Bidomain model of cardiac tissue with active membrane properties (numerical calculations)
I
Intervention
Electrical stimulation (cathodal and anodal)
O
Outcome
Response of cardiac muscle to stimulation (wavefront speed, virtual cathode size and shape, threshold current strength)

A bidomain model of cardiac tissue demonstrates that virtual cathode size and shape depend on membrane and tissue conductivities, with differing threshold currents for cathodal and anodal stimuli.

Cite This Study

Roth et al. (1994) studied this question.

synapsesocial.com/papers/6a2080f3df4cd797f4f4228dhttps://doi.org/10.1109/10.284941
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Also Consider

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  1. 1Effect of tissue anisotropy on extracellular potential fields in canine myocardium in situ.1982 · 247 citations
  2. 2Directional differences of impulse spread in trabecular muscle from mammalian heart.1976 · 665 citations
  3. 3Direct Current Make and Break Thresholds for Pacemaker Electrodes on the Canine Ventricle1970 · 96 citations
  4. 4A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.1991 · 1,482 citations
  5. 5A Mechanism for Anisotropic Reentry in Electrically Active Tissue1992 · 34 citations