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January 1, 1993IEEE Transactions on Biomedical Engineering

A model study of extracellular stimulation of cardiac cells

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Key result

In a computational myocyte model, a biphasic pulse constituted the best choice for maximum efficacy of cardiac cell excitation at all phases of the action potential.

Population

Myocyte model using a modified Beeler-Reuter model for Na+ dynamics

Comparison

Point source extracellular stimulation with… vs Comparison between different pulse shapes and…

Design

Preclinical

Authors

LLL.J. LeonFRF.A. Roberge

Discussion

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Overview

Biphasic pulses may optimize modeled myocyte excitation across phases; leaves open validation in tissue or clinical devices.

Key Points

  • To evaluate how different pulse stimuli affect extracellular stimulation of cardiac myocytes during the cardiac cycle.
  • Point source stimulation applied to a myocyte model shaped as a cylinder (10 microns in diameter, 100 microns in length).
  • Beeler-Reuter model modified for Na+ dynamics used to simulate ionic currents.
  • Different pulse shapes and timings assessed for efficacy during cardiac action potential phases.
  • Cathodal pulses are the most effective at diastolic potentials, enhancing stimulation efficacy.
  • Anodal pulses are preferable during the plateau phase of the action potential.
  • Biphasic pulses provide optimal efficacy across all action potential phases.

Structured PICO

P
Population
Myocyte model (small cylinder of membrane, 10 microns diameter, 100 microns length) using a modified Beeler-Reuter model for Na+ dynamics
I
Intervention
Point source extracellular stimulation with varying pulse shapes (cathodal, anodal, biphasic) and timing
C
Comparator
Comparison between different pulse shapes and timing in the cardiac cycle
O
Outcome
Efficacy of excitation of cardiac cellssurrogate

A computational model demonstrates that a biphasic pulse provides the maximum efficacy for extracellular stimulation of cardiac cells across all phases of the action potential.

Cite This Study

Leon et al. (1993) studied Cardiac cell excitation. Extracellular stimulation (cathodal, anodal, and biphasic pulses) was evaluated on Efficacy of excitation of cardiac cells at different phases of the action potential. In a computational myocyte model, a biphasic pulse constituted the best choice for maximum efficacy of cardiac cell excitation at all phases of the action potential.

synapsesocial.com/papers/6a6c210847a1bfb288f36aefhttps://doi.org/10.1109/10.250586
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Periodic Conductivity as a Mechanism for Cardiac Stimulation and Defibrillation1987 · 116 citations
  2. 2Influence of electrical axis of stimulation on excitation of cardiac muscle cells.1991 · 98 citations
  3. 3Extracellular field required for excitation in three-dimensional anisotropic canine myocardium.1988 · 96 citations
  4. 4Improved cardiac cell excitation with symmetrical biphasic defibrillator waveforms1987 · 99 citations
  5. 5A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.1991 · 1,483 citations