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March 1, 1990IEEE Transactions on Biomedical Engineering

Potential distribution in three-dimensional periodic myocardium. II. Application to extracellular stimulation

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Population

Three-dimensional periodic myocardium model and animal experiments

Design

Preclinical

Authors

WKWanda KrassowskaU.S. National Science FoundationDFDavid W. FrazierHeart Rhythm SocietyTPT.C. PilkingtonNational Institutes of Health

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Overview

Validates asymptotic models for myocardial stimulation in animals; leaves open human translation and clinical testing.

Key Points

  • This research aims to model potential distribution in the myocardium as a periodic structure during extracellular stimulation.
  • Developed a model comparing potential distributions with experimental data.
  • Considered factors like conductivity, fiber orientation, and stimulus strength in simulations.
  • Generalized stimulation threshold concepts to three dimensions, constructing an excitability surface.
  • Numerical values from the model align with experimental results from animal studies, validating the approach.
  • The model establishes relationships between large-scale field parameters and transmembrane potential.
  • It shows that stimulation thresholds depend on fiber orientation and mapping of current density.

Structured PICO

P
Population
Three-dimensional periodic myocardium model and animal experiments
I
Intervention
High-current stimulation with extracellular electrodes
O
Outcome
Distributions of potential, potential gradient, transmembrane potential, and stimulation thresholdsurrogate

A mathematical model of three-dimensional periodic myocardium accurately predicts transmembrane potential and stimulation thresholds during extracellular stimulation, agreeing with animal experimental data.

Cite This Study

Krassowska et al. (1990) studied this question.

synapsesocial.com/papers/6a1bf8811567d2fc4d5f5926https://doi.org/10.1109/10.52328
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Periodic Conductivity as a Mechanism for Cardiac Stimulation and Defibrillation1987 · 116 citations
  2. 2Extracellular field required for excitation in three-dimensional anisotropic canine myocardium.1988 · 96 citations
  3. 3Improved cardiac cell excitation with symmetrical biphasic defibrillator waveforms1987 · 99 citations
  4. 4Influence of cardiac fiber orientation on wavefront voltage, conduction velocity, and tissue resistivity in the dog.1979 · 440 citations
  5. 5Directional differences of impulse spread in trabecular muscle from mammalian heart.1976 · 664 citations