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September 1, 1995Pacing and Clinical Electrophysiology

Effects of Electroporation on Transmembrane Potential Induced by Defibrillation Shocks

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Population

One-dimensional model of cardiac strand

Design

Preclinical

Authors

WKWanda Krassowska

Discussion

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Overview

Electroporation may limit near-electrode damage during defibrillation; leaves open whether this mechanism alters clinical shock protocols or requires in vivo confirmation.

Structured PICO

P
Population
One-dimensional model of cardiac strand
I
Intervention
Defibrillation shocks via extracellular electrodes inducing electroporation
O
Outcome
Transmembrane potential (Vm)surrogate

Electroporation during defibrillation shocks limits excessive transmembrane potential growth near electrodes, potentially preventing tissue damage without impairing shock delivery to distant myocardium.

Cite This Study

Wanda Krassowska (1995) studied this question.

synapsesocial.com/papers/6a2080f3df4cd797f4f4228chttps://doi.org/10.1111/j.1540-8159.1995.tb06986.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Electroporation on the Transmembrane Potential Distribution in a Two‐Dimensional Bidomain Model of Cardiac Tissue1999 · 43 citations
  2. 2Effects of electroporation on optically recorded transmembrane potential responses to high-intensity electrical shocks2004 · 49 citations
  3. 3Effect of Electroporation on Cardiac Electrophysiology2008 · 37 citations
  4. 4The Role of Electroporation in Defibrillation2000 · 154 citations
  5. 5Nonlinear Changes of Transmembrane Potential During Electrical Shocks2003 · 50 citations