Why the study?
Does electroporation from defibrillation shocks affect cardiac electrophysiology?
Population
Cardiac tissue
Design
Review
Key result
Electroporation in cardiac tissue occurs above a threshold of 25 V/cm, causing electrophysiological changes that can induce tachyarrhythmia but also provide a foundation for gene and drug delivery.
Authors
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Electroporation from defibrillation may promote arrhythmias; leaves open its role in cardiac gene and drug delivery for future study.
Does electroporation from defibrillation shocks affect cardiac electrophysiology?
Electroporation during defibrillation causes significant electrophysiological changes that can be proarrhythmic, but also provides a potential mechanism for targeted gene and drug delivery to cardiac tissues.
Fedorov et al. (2008) conducted a review in Arrhythmia. Electroporation was evaluated on Electrophysiological changes. Electroporation in cardiac tissue occurs above a threshold of 25 V/cm, causing electrophysiological changes that can induce tachyarrhythmia but also provide a foundation for gene and drug delivery.
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