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March 1, 1996Proceedings of the IEEE

High intensity electrical fields produce electrical dysfunction at various structural levels of the heart, primarily through electroporation of the cell membrane, as well as formation of oxygen-derived free radicals, conformational damage, barotrauma, and hyperthermia.

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Population

Animal models used to study cardiac electrical dysfunction

Design

Review

Authors

LTLeslie Tung

Discussion

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Overview

Alerts clinicians to myocardial injury risks from high-energy shocks; leaves open optimization of defibrillation parameters for safer arrhythmia therapy.

Structured PICO

P
Population
Animal models used to study cardiac electrical dysfunction
I
Intervention
High intensity electrical fields (controlled electrical shock)
O
Outcome
Electrical dysfunction and tissue injury at various structural levels of the heartsafety

High-intensity electrical shocks used for arrhythmia management can cause cardiac tissue injury and dysfunction through mechanisms such as electroporation and free radical formation.

Cite This Study

Leslie Tung (1996) studied this question.

synapsesocial.com/papers/6a1c08c9ea84844e355f599ehttps://doi.org/10.1109/5.486740
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conduction disturbances caused by high current density electric fields.1990 · 156 citations
  2. 2Cardiac Arrhythmias Following Condenser Discharges and Their Dependence Upon Strength of Current and Phases of Cardiac Cycle1963 · 101 citations
  3. 3Efficacy and safety of defibrillation with rectangular waves of 2− to 20-milliseconds duration1983 · 26 citations
  4. 4Cell-attached patch clamp study of the electropermeabilization of amphibian cardiac cells1991 · 84 citations
  5. 5Three-dimensional potential gradient fields generated by intracardiac catheter and cutaneous patch electrodes.1992 · 92 citations