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April 1, 1986CirculationOpen Access

The cellular electrophysiologic changes induced by high-energy electrical ablation in canine myocardium.

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Why the study?

Does high-energy electrical ablation induce cellular electrophysiologic changes and tissue injury in canine myocardium in vitro?

Population

14 epicardial tissues from 11 dogs

Design

Preclinical

Follow-up

immediately after delivery

Authors

JLJ H LevineSt. Francis HospitalJSJ F SpearNew York University PressHWHarlan F. WeismanInterventional / Structural Cardiology

Discussion

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Overview

High-energy ablation may induce remote myocardial injury; hypothesis-generating for arrhythmogenic mechanisms, requiring human validation.

Structured PICO

Does high-energy electrical ablation induce cellular electrophysiologic changes and tissue injury in canine myocardium in vitro?

P
Population
14 epicardial tissues from 11 dogs
I
Intervention
High-energy electrical shocks (5 to 40 J) delivered in vitro
O
Outcome
Cellular electrophysiologic effects (resting membrane potential, action potential amplitude, dV/dT, impulse conduction, repolarization)surrogate

High-energy electrical ablation induces graded cellular electrophysiologic abnormalities and contraction band necrosis in canine myocardium, providing insights into potential arrhythmogenic mechanisms.

Cite This Study

Levine et al. (1986) studied this question.

synapsesocial.com/papers/6a71981f75498292b70b04e6https://doi.org/10.1161/01.cir.73.4.818
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Also Consider

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  1. 1Closed-chest electrode-catheter technique for His bundle ablation in dogs1981 · 145 citations
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  4. 4Ventricular Resection Guided by Epicardial and Endocardial Mapping for Treatment of Recurrent Ventricular Tachycardia1980 · 319 citations
  5. 5Directional differences of impulse spread in trabecular muscle from mammalian heart.1976 · 664 citations