This report reviews the biophysical aspects of lesion formation using radiofrequency energy for catheter ablation in a canine model.
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May inform RF lesion parameters in ablation; leaves open human translation and safety data.
High energy direct-current shocks delivered via an electrode catheter have been used to ablate the atrioventricular junction since 1981. This technique has also been adapted for ablation of other cardiac tissues including the atrium, posterior interatrial septum and ventricular myocardium. The limitations of this technique include inadequate control of the energy source, poor understanding of the mechanisms of myocardial injury, and untoward complications possibly related to barotraumatic injury. Radiofrequency energy has been shown to create ablative injury when delivered to the myocardium via standard electrode catheters. This report will review our experience with radiofrequency catheter ablation of the canine myocardium with specific emphasis on the biophysical aspects of lesion formation.
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Franklin et al. (1989) studied this question.
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