Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids

Lanyu Zhou; Haiyue Gong; Huan Zhao; Luqi Huang; Yating Hu

doi:10.1039/d5np00089k

January 1, 2026Natural Product Reports

Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids

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Key Points

This review aims to evaluate the recent progress in understanding biosynthetic pathways of plant alkaloids and explore synthetic biology applications.
Analysis of advances in plant alkaloid biosynthesis from 2018 to 2025
Discussion of challenges in stereochemical control, cyclization, and tailoring modifications
Evaluation of synthetic biology strategies for microbial production
Identified key challenges in controlling stereochemistry and modifications of plant alkaloids
Highlighted innovative microbial production strategies for alkaloids using synthetic biology

Implication

Review analyzes challenges in plant alkaloid biosynthesis and synthetic biology strategies for microbial production.

Abstract

This review analyzes advances in plant alkaloid biosynthesis (2018–2025), highlighting key challenges in stereochemical control, cyclization, and tailoring modifications, and discusses synthetic biology strategies for microbial production.

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a05685ca550a87e60a20f15 https://doi.org/10.1039/d5np00089k

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Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids

Key Points

Implication

Abstract

Discussion

Cite This Study

Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids

Key Points

Implication

Abstract

Discussion

Cite This Study

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