Key result
Review outlines a contemporary framework for diagnosing and managing inflammatory myocardial and pericardial syndromes.
Why the study?
Inflammatory myocardial and pericardial syndromes constitute a heterogeneous group of immune-mediated cardiac disorders with diverse clinical trajectories ranging from complete recovery to progressive heart failure and sudden death.
This state-of-the-art review provides a contemporary framework for the diagnosis and management of inflammatory myocardial and pericardial syndromes, integrating multimodality imaging, genetic testing, and targeted therapies.
Answers are grounded in this paper and cite their sources.
May guide individualized diagnosis of inflammatory cardiac syndromes; leaves open prospective validation of integrated imaging-genetic strategies.
Inflammatory myocardial and pericardial syndromes (IMPS), including myocarditis, pericarditis, and overlapping myopericardial syndromes, constitute a heterogeneous group of immune-mediated cardiac disorders with clinical trajectories ranging from complete recovery to progressive heart failure and sudden death. This state-of-the-art review synthesizes current insights into immunopathogenesis, emphasizing the interplay among genetic susceptibility, environmental factors, and systemic inflammatory drivers, including rheumatological diseases. A pragmatic diagnostic framework is presented; it integrates targeted serological evaluation, genetic testing, multimodality imaging, and selective endomyocardial biopsy to enable precise etiologic classification. Therapeutic strategies are examined across the spectrum of disease severity, including guideline-directed medical therapy for heart failure, immunosuppression for autoimmune and fulminant phenotypes, and cytokine-directed biologics for recurrent pericarditis. Prognostic determinants, indications for advanced heart failure therapies, and emerging directions in precision immunology, molecular profiling, and AI-enabled risk stratification are discussed to guide future clinical and translational advances.
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LOTAN et al. (2026) conducted a review in Inflammatory myocardial and pericardial syndromes (IMPS). This state-of-the-art review provides a contemporary framework for the diagnosis, etiologic classification, and management of inflammatory myocardial and pericardial syndromes.
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