What question did this study set out to answer?

To examine the relationship between amyloid chronicity and clinical symptoms in Alzheimer's disease over time.

January 1, 2022Alzheimer s & Dementia Diagnosis Assessment & Disease MonitoringOpen Access

Trajectory of clinical symptoms in relation to amyloid chronicity

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To examine the relationship between amyloid chronicity and clinical symptoms in Alzheimer's disease over time.
123 participants diagnosed as A+ using [C-11]Pittsburgh compound B PET imaging
A longitudinal assessment of clinical symptoms using CDR-SB was conducted
Exploratory analyses on age and white matter hyperintensities were included.
Average amyloid chronicity at CDR-SB of 2.5 was 20.1 years
CDR-SB trajectory accelerated after 10 years of elevated amyloid with variability between 10 and 30 years
Older age and higher volume of white matter hyperintensities were associated with a shortened interval to cognitive impairment.

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Implication

Randomized trial examines amyloid burden's effect on cognitive impairment timeline in Alzheimer's patients, suggesting implications for prognosis and care.

Cite This Study

Birdsill et al. (2022) studied this question.

synapsesocial.com/papers/6a05b4e74613799ff7a2057d https://doi.org/10.1002/dad2.12360

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Implication

Randomized trial examines amyloid burden's effect on cognitive impairment timeline in Alzheimer's patients, suggesting implications for prognosis and care.

Trajectory of clinical symptoms in relation to amyloid chronicity

Key Points

Discussion

Implication

Cite This Study

Trajectory of clinical symptoms in relation to amyloid chronicity

Key Points

Discussion

Implication

Cite This Study

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