What question did this study set out to answer?

This research aims to evaluate whether CD4+ T-cell counts continue to increase over long periods on combination antiretroviral therapy (ART).

May 13, 2010AIDS

Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection

View Full Paper

Ask AI

Bookmark

This research aims to evaluate whether CD4+ T-cell counts continue to increase over long periods on combination antiretroviral therapy (ART).
Included 898 US patients initiating ART in a randomized trial.
Used inverse probability of censoring weighting statistical methods to analyze long-term CD4 cell count trajectory.
Categorized patients based on pretreatment CD4 cell counts.
Median CD4 cell count increased from 270 cells/microl pre-ART to an estimated 556 cells/microl at 3 years.
If ART had continued, the estimated median at 7 years would have been 640 cells/microl.
25% of patients with pretreatment CD4 counts of 200 or less still had low counts (<350 cells/microl) after 7 years.

No takes yet. Share an insight, caveat, or question.

Randomized trial investigates long-term CD4+ T-cell count increase in HIV-1 patients, suggesting earlier ART initiation may be beneficial.

Lok et al. (2010) studied this question.

View Full Paper

Ask AI

Bookmark

Randomized trial investigates long-term CD4+ T-cell count increase in HIV-1 patients, suggesting earlier ART initiation may be beneficial.