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July 27, 2005New England Journal of MedicineOpen Access

Perioperative Beta-Blocker Therapy and Mortality after Major Noncardiac Surgery

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Why the study?

Does perioperative beta-blocker therapy reduce in-hospital mortality in patients undergoing major noncardiac surgery?

Population

782,969 patients 18 years of age or older who underwent major noncardiac surgery in 2000 and 2001 at 329…

Comparison

Perioperative beta-blockers administered during… vs No perioperative beta-blocker therapy

Design

Cohort

Follow-up

in-hospital

Authors

PLPeter K. LindenauerPPPenelope S. PekowKWKaijun Wang

Discussion

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Overview

May support risk-stratified beta-blocker use by RCRI in noncardiac surgery; leaves open randomized confirmation of mortality benefit.

Structured PICO

Does perioperative beta-blocker therapy reduce in-hospital mortality in patients undergoing major noncardiac surgery?

P
Population
782,969 patients 18 years of age or older who underwent major noncardiac surgery in 2000 and 2001 at 329 hospitals throughout the United States.
I
Intervention
Perioperative beta-blockers administered during the first two hospital days
C
Comparator
No perioperative beta-blocker therapy (propensity-score matched)
O
Outcome
In-hospital mortalityhard clinical

Perioperative beta-blocker therapy is associated with reduced in-hospital mortality in high-risk patients (RCRI ≥2) undergoing major noncardiac surgery, but may cause harm in low-risk patients.

Cite This Study

Lindenauer et al. (2005) studied this question.

synapsesocial.com/papers/6a062a99ac5820011f109cd2https://doi.org/10.1056/nejmoa041895
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