Key result
Global calcific aortic valve disease affects males at a ~50% higher rate than females.
Why the study?
The study was conducted to analyze the sex and age distribution of the global disease burden of calcific aortic valve disease from 1990 to 2021.
Observational (n=13,320,000)
Absolute Event Rate: 193.2% vs 128.9%
There are significant gender and age disparities in the global burden of calcific aortic valve disease, highlighting the need for targeted interventions in the elderly, particularly super-elderly females.
OBJECTIVES: To analyze sex and age distribution of global disease burden of calcific aortic valve disease (CAVD) from 1990 to 2021. METHODS: CAVD data during 1990-2021 were obtained from the IHME website for Global Burden of Disease (GBD). The prevalence, mortality, years lived with disability (YLDs), and disability-adjusted life years (DALYs) were analyzed by gender and age groups. Joinpoint regression was used to calculate annual percentage change (APC) and average annual percentage change (AAPC). RESULTS: ). YLD rates increased with age, and were higher in males for all age groups. DALY rates decreased overall but increased in ≥85 years old, with a greater increase in females. CONCLUSIONS: There are significant gender and age disparities in global disease burden of CAVD, with the elderly, especially super-elderly females deserving particular attention. It is recommended to develop personalized intervention strategies for these populations.
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Deng et al. (2025) conducted an observational in Calcific aortic valve disease (n=13,320,000). Male sex vs. Female sex was evaluated on Age-standardized prevalence per 100,000 in 2021. Global calcific aortic valve disease burden showed significant sex and age disparities, with higher overall age-standardized prevalence in males (193.2/100,000) compared to females (128.9/100,000).
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