Key result
High arrhythmia scores in canines are linked to a ~198% increase in short-term repolarization variability.
Why the study?
Understanding mechanisms initiating ventricular arrhythmias and factors determining their severity has the potential to uncover new interventions.
Does the increment of short-term variability of repolarisation determine the severity of imminent torsades de pointes in a canine model?
Does the increment of short-term variability of repolarisation determine the severity of imminent torsades de pointes in a canine model?
Absolute Event Rate: 197.5% vs 90.83%
p-value: p=0.0414
Short-term variability of repolarisation serves as a key marker for the initiation and severity of torsades de pointes in experimental models.
STV may mark arrhythmia severity in canine models; leaves open human validation before clinical use.
Ventricular remodelling can make the heart more susceptible to ventricular arrhythmias like torsades de pointes. Understanding the underlying mechanisms of initiation of ventricular arrhythmias and the determining factors for its severity has the potential to uncover new interventions. Beat-to-beat variation of repolarisation, quantified as short-term variability of repolarisation (STV), has been identified as an important factor contributing to arrhythmogenesis. This article provides an overview of experimental data about STV in relation to the initiation of torsades de pointes in a canine model of complete chronic atrioventricular block susceptible to torsades de pointes arrhythmias. Furthermore, it explores STV in relation to the severity of the arrhythmic outcome.
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Smoczyńska et al. (2019) conducted a review in Ventricular arrhythmias (Torsades de Pointes) (n=64). Dofetilide vs. Baseline was evaluated on Relative increase in Short-term Variability of Repolarisation (∆STV) in high vs low Arrhythmia Score groups (p=0.0414). In a canine model, the relative increase in short-term variability of repolarisation was significantly higher in dogs with a high arrhythmia score (197.5%) compared to a low score (90.8%).
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