Key result
Dofetilide induced torsade de pointes in 55.6% of dogs with chronic AV block (ventricular remodelling) compared to 0% of dogs with acute AV block (P<0.001).
Why the study?
Does ventricular remodelling predispose to dofetilide-induced torsade de pointes in an anaesthetized dog model of atrio-ventricular block?
Population
32 anaesthetized dogs with complete atrio-ventricular block, evaluated in the presence of ventricular…
Comparison
Dofetilide 0.025 mg/kg/5 min intravenously in… vs Dofetilide 0.025 mg/kg/5 min intravenously in…
Design
Preclinical
Authors
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May refine TdP risk assessment on QT drugs; leaves open validation in human studies.
Does ventricular remodelling predispose to dofetilide-induced torsade de pointes in an anaesthetized dog model of atrio-ventricular block?
Absolute Event Rate: 55.6% vs 0%
p-value: p=< 0.001
Ventricular remodelling is a prerequisite for dofetilide-induced torsade de pointes in the complete atrio-ventricular-block dog model.
Dunnink et al. (2011) studied Dofetilide-induced torsade de pointes arrhythmias (n=32). Dofetilide in chronic atrio-ventricular block (ventricular remodelling) vs. Dofetilide in acute atrio-ventricular block (no ventricular remodelling) was evaluated on Torsade de pointes inducibility (reproducible ≥ 3 times occurrence) (p=< 0.001). Dofetilide induced torsade de pointes in 55.6% of dogs with chronic AV block (ventricular remodelling) compared to 0% of dogs with acute AV block (P<0.001).
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