Key result
Negative feedback ion currents restrict cardiac action potential duration variability alongside calcium and redox potential.
Beat-to-beat variability of action potential duration is a strong predictor of arrhythmia, modulated by specific ion currents (ICa, IKr, IKs, INa), intracellular calcium, and redox potential.
APD variability mechanisms may refine arrhythmia prediction; leaves open targeted therapies based on calcium/redox modulation.
, suggesting that ion currents involved in the negative feedback regulation of APD tend to keep RSV at a low level. RSV is also influenced by intracellular calcium concentration and tissue redox potential. The clinical implications of APD variability is discussed in detail.
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Nánási et al. (2017) studied this question. Cardiac action potential duration variability is maintained at low levels by negative feedback ion currents and is influenced by intracellular calcium concentration and tissue redox potential.
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