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July 24, 2025Cardiovascular UltrasoundOpen Access

Left atrium phasic function decreases in adult patients with repaired tetralogy of fallot: a case–control study

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Why the study?

Although the left atrium plays a key role in diastolic function, left atrial dysfunction in patients with repaired tetralogy of Fallot remains unclear.

Does repaired tetralogy of Fallot reduce left atrial phasic function across different age groups compared to healthy controls?

Population

Patients with repaired tetralogy of Fallot across three age groups and healthy controls

Comparison

Patients with repaired tetralogy of Fallot vs healthy controls across three age groups

Design

Case-control study

Authors

KSKeiya SatoKTKen TakahashiYAYusuke Akatsuka

Discussion

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Overview

Reduced LA strains may signal early diastolic changes in adult rTOF; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

Does repaired tetralogy of Fallot reduce left atrial phasic function across different age groups compared to healthy controls?

P
Population
62 patients with repaired tetralogy of Fallot (rTOF) aged 3-44 years (divided into T1: 3-9 years, T2: 10-19 years, T3: 20-44 years) and 62 age- and sex-matched healthy controls (C1, C2, C3). Key inclusion for rTOF: normal sinus rhythm, absence of chromosomal defects, absence of other systemic diseases.
C
Comparator
Age- and sex-matched healthy controls without history of cardiovascular disease, with normal sinus rhythm and normal echocardiographic findings.
O
Outcome
Left atrial (LA) phasic function (reservoir, conduit, and pump strains) assessed by two-dimensional speckle-tracking echocardiography.surrogate

Left atrial reservoir and pump strains are significantly reduced in adult patients with repaired tetralogy of Fallot, suggesting these parameters may serve as sensitive early indicators of diastolic dysfunction.

Cite This Study

Sato et al. (2025) studied this question.

synapsesocial.com/papers/6a0662f33f8bf83a443dd99chttps://doi.org/10.1186/s12947-025-00355-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between right ventricular enlargement, QRS duration, and right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation after surgical repair2000 · 159 citations
  2. 2Exercise Intolerance in Adult Congenital Heart Disease2005 · 890 citations
  3. 3Prognostic value of left atrial size and function in adults with tetralogy of Fallot2017 · 37 citations
  4. 4Left Ventricular Torsion and Strain in Patients with Repaired Tetralogy of Fallot Assessed by Speckle Tracking Imaging2011 · 41 citations
  5. 5Left Atrial Function and Maximal Exercise Capacity in Heart Failure with Preserved and Mid-Range Ejection Fraction2020 · 42 citations