Key result
Larger indexed aortic root diameter is linked to aging, hypertension, and diastolic dysfunction in asymptomatic Asians.
Why the study?
Normal reference ranges for aortic root diameter in Asians and their correlates with diastolic dysfunction using contemporary guidelines remain largely unexplored.
Is echocardiography-defined aortic root diameter associated with diastolic dysfunction and cardiac structure/function in asymptomatic Asians?
Observational (n=5,343)
Is echocardiography-defined aortic root diameter associated with diastolic dysfunction and cardiac structure/function in asymptomatic Asians?
In asymptomatic Asians, a larger indexed aortic root diameter measured by echocardiography is a useful indicator for identifying baseline abnormal diastolic dysfunction.
Answers are grounded in this paper and cite their sources.
May flag diastolic dysfunction on routine echo in asymptomatic Asians; hypothesis-generating, needs prospective validation before clinical use.
BACKGROUND: The aortic root diameter (AoD) has been shown to be a marker of cardiovascular risk and heart failure (HF). Data regarding the normal reference ranges in Asians and their correlates with diastolic dysfunction using contemporary guidelines remain largely unexplored. METHODS: Among 5343 consecutive population-based asymptomatic Asians with echocardiography evaluations for aortic root diameter (without/with indexing, presented as AoD/AoDi) were related to cardiac structure/function and N-terminal pro-brain B-type natriuretic peptide (Nt-ProBNP), with 245 participants compared with multidetector computed tomography (MDCT)-based aortic root geometry. RESULTS: for ∆AUROC: < 0.001). These associations were broadly weaker for AoD. CONCLUSION: In our large asymptomatic Asian population, echocardiography-defined aortic root dilation was associated with aging and hypertension and were correlated modestly with computed tomography measures. A larger indexed aortic diameter appeared to be a useful indicator in identifying baseline abnormal diastolic dysfunction.
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Liu et al. (2020) conducted an observational in Asymptomatic (n=5,343). Echocardiography-defined aortic root diameter (AoD/AoDi) vs. Multidetector computed tomography (MDCT) was evaluated on Diastolic dysfunction and cardiac structure/function (p=< 0.001). Larger indexed aortic root diameter on echocardiography was associated with aging, hypertension, and baseline abnormal diastolic dysfunction in asymptomatic Asians (P<0.001 for ∆AUROC).
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