What is the clinical evidence from this study?

Study design: Observational. Population: Severe aortic valve stenosis at low surgical risk (n=20549). Intervention: Transcatheter aortic valve implantation (TAVI) vs. Surgical aortic valve replacement (SAVR). Primary outcome: 1-year survival (p=0.158).

What question did this study set out to answer?

This research analyzes outcomes for low surgical risk patients treated with TAVI or SAVR based on registry data.

October 9, 2018European Heart JournalOpen Access

Patients at low surgical risk as defined by the Society of Thoracic Surgeons Score undergoing isolated interventional or surgical aortic valve implantation: in-hospital data and 1-year results from the German Aortic Valve Registry (GARY)

Q: What are the key findings of this study?

In low-risk patients, TAVI demonstrated similar 1-year survival compared to SAVR (90.0% vs. 91.2%; P=0.158) and significantly higher in-hospital survival (98.5% vs. 97.3%; P=0.003).

View Full Paper

Ask AI

Bookmark

Key result

TAVI is associated with similar 1-year but higher in-hospital survival vs SAVR in low-risk patients.

P=0.158
n=20,549

Why the study?

Does transcatheter aortic valve implantation improve survival compared to surgical aortic valve replacement in patients with severe aortic valve stenosis at low surgical risk?

Population

20,549 patients with severe aortic valve stenosis at low surgical risk undergoing isolated TAVI or SAVR in…

Comparison

Transcatheter aortic valve implantation (TAVI) vs Surgical aortic valve replacement (SAVR)

Design

Cohort

Follow-up

1 year

Authors

RBRaffi BekeredjianInterventional Cardiology GSGábor SzabóSemmelweis University ÜBÜmniye BalabanGoethe University Frankfurt

Discussion

Member takes

Implication

TAVI was associated with higher short-term but similar 1-year survival versus SAVR in low-risk patients; leaves open need for confirmatory randomized trials.

Key Points

This research analyzes outcomes for low surgical risk patients treated with TAVI or SAVR based on registry data.
Evaluated patients with Society of Thoracic Surgeons Score <4% undergoing TAVI or SAVR in 2014 and 2015
Total of 20,549 low surgical risk patients included, with a weighted propensity score model used for analysis
Outcomes assessed included in-hospital, 30-day, and 1-year mortality rates.
In-hospital survival rates were 98.5% for TAVI vs. 97.3% for SAVR (P=0.003)
30-day survival rates were 98.1% for TAVI vs. 97.1% for SAVR (P=0.014)
1-year survival rates were similar at 90.0% for TAVI vs. 91.2% for SAVR (P=0.158)

Study Design

Type

Observational (n=20,549)

Multicenter

Yes

Structured PICO

Does transcatheter aortic valve implantation improve survival compared to surgical aortic valve replacement in patients with severe aortic valve stenosis at low surgical risk?

Population

20,549 patients with severe aortic valve stenosis at low surgical risk (Society of Thoracic Surgeons Score <4%) undergoing isolated TAVI or SAVR in 2014 and 2015 from the German Aortic Valve Registry (GARY)

Intervention

Transcatheter aortic valve implantation (TAVI)

Comparator

Surgical aortic valve replacement (SAVR)

Outcome

In-hospital, 30-day, and 1-year survivalhard clinical

Main Result

Absolute Event Rate: 90% vs 91.2%

p-value: p=0.158

In low-surgical-risk patients with severe aortic stenosis, TAVI is associated with higher short-term survival but similar 1-year survival compared to SAVR.

Cite This Study

Bekeredjian et al. (2018) conducted an observational in Severe aortic valve stenosis at low surgical risk (n=20,549). Transcatheter aortic valve implantation (TAVI) vs. Surgical aortic valve replacement (SAVR) was evaluated on 1-year survival (p=0.158). In low-risk patients, TAVI demonstrated similar 1-year survival compared to SAVR (90.0% vs. 91.2%; P=0.158) and significantly higher in-hospital survival (98.5% vs. 97.3%; P=0.003).

synapsesocial.com/papers/6a066409cc83fae8617783ce https://doi.org/10.1093/eurheartj/ehy699

Topics

TAVR in low-risk patients Transcatheter aortic valve replacement

View Full Paper

Ask AI

Bookmark

Implication

TAVI was associated with higher short-term but similar 1-year survival versus SAVR in low-risk patients; leaves open need for confirmatory randomized trials.

Patients at low surgical risk as defined by the Society of Thoracic Surgeons Score undergoing isolated interventional or surgical aortic valve implantation: in-hospital data and 1-year results from the German Aortic Valve Registry (GARY)

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Patients at low surgical risk as defined by the Society of Thoracic Surgeons Score undergoing isolated interventional or surgical aortic valve implantation: in-hospital data and 1-year results from the German Aortic Valve Registry (GARY)

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider