Key result
Leakage function models do not change vFFR vs 1D models but alter volumetric flow and CFR.
Why the study?
Does a model with a leakage function accounting for side branch flow improve the prediction of physiological indices compared to an original 1D model in patients undergoing coronary angiography?
Observational (n=80)
Does a model with a leakage function accounting for side branch flow improve the prediction of physiological indices compared to an original 1D model in patients undergoing coronary angiography?
Accounting for side branch flow significantly impacts estimated volumetric flow rate and coronary flow reserve, but not vFFR, suggesting caution when using vFFR to quantitatively assess flow.
vFFR remains robust to side-branch leakage modeling; leaves open accurate volumetric flow and CFR prediction in 1D coronary models.
) and the original model (1D) were then applied to predict FFR as well as inlet and outlet flow in 146 arteries from 80 patients who underwent invasive coronary angiography and FFR measurement. The results show that the leakage function did not significantly change the vFFR but did significantly impact the estimated volumetric flow rate and predicted coronary flow reserve. As both procedures achieved similar predictive accuracy of vFFR despite large differences in coronary blood flow, these results suggest careful consideration of the application of this index for quantitatively assessing flow.
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Gosling et al. (2020) conducted an observational in Coronary artery disease (n=80). Leakage function model vs. Original 1D model was evaluated on vFFR, estimated volumetric flow rate, and predicted coronary flow reserve. Applying a leakage function model did not significantly change vFFR compared to the original 1D model, but significantly impacted estimated volumetric flow rate and predicted coronary flow reserve.
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