Key result
Severe preoperative frailty is linked to ~10-fold higher 30-day mortality risk across noncardiac surgeries.
Why the study?
Whether the association between frailty and postoperative mortality is consistent across all surgical specialties, particularly those predominantly performing lower stress procedures, was unknown.
Does preoperative frailty increase 30-day and 180-day postoperative mortality in adult patients undergoing noncardiac surgery?
Population
Patients 18 years or older undergoing noncardiac procedures across 9 noncardiac specialties (NSQIP n = 2 339 031; VASQIP n = 426 578)
Comparison
Frailty tiers by Risk Analysis Index: robust, normal, frail, or very frail across procedure stress levels
Design
Cohort study
Follow-up
30 days (NSQIP and VASQIP) and 180 days (VASQIP only)
Authors
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Frailty screening may refine preoperative risk assessment across noncardiac specialties; leaves open whether targeted interventions improve survival.
Does preoperative frailty increase 30-day and 180-day postoperative mortality in adult patients undergoing noncardiac surgery?
Preoperative frailty is a strong, independent predictor of postoperative mortality across all noncardiac surgical specialties, regardless of procedural stress level.
George et al. (2020) studied this question. Preoperative frailty was an independent risk factor for 30-day mortality across all noncardiac surgical specialties, with very frail patients facing significantly higher odds of death (aOR 9.8-27.99).
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