May 15, 2026Journal of the American College of Cardiology
Annual Outcomes With Transcatheter Valve Therapy
Key result
U.S. TAVR trends show a ~25% reduction in vascular complications with stable stroke rates.
- n=26,414
Why the study?
To provide an overview of current US transcatheter valve therapy practice, trends, demographics, in-hospital procedural characteristics, and outcomes of patients undergoing TAVR.
What are the current practice trends, patient characteristics, and in-hospital outcomes for TAVR in the United States?
Population
26,414 TAVR procedures at 348 U.S. centers
Comparison
Procedures performed in 2012 and 2013 vs 2014
Design
Registry-based temporal trends analysis
Authors
Discussion
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Implication
Tracks evolving TAVR techniques amid stable stroke rates; extends registry observations but leaves causal links open.
Key Points
- This report aims to present an overview of current practices and outcomes associated with TAVR in U.S. centers.
- Analysis of data from the STS/ACC Transcatheter Valve Therapy Registry, capturing 26,414 TAVR procedures.
- Comparison of patient demographics and procedural characteristics between 2012-2013 and 2014.
- Focus on changes in sedation use, access techniques, and complication rates.
- Patient mean age is 82 years with a high STS predicted risk of mortality at 8.34%.
- Vascular complication rates decreased from 5.6% to 4.2%, while stroke rates remained stable at 2.2%.
- Increased use of moderate sedation for procedures from 1.6% to 5.1% and a rise in femoral access techniques to 66.8%.
Study Design
Type
Observational (n=26,414)
Multicenter
Yes
Structured PICO
What are the current practice trends, patient characteristics, and in-hospital outcomes for TAVR in the United States?
P
Population
26,414 patients undergoing transcatheter aortic valve replacement (TAVR) at 348 U.S. centers, mean age 82 years, high mean STS PROM (8.34%), NYHA III/IV in 82.5%, frail (slow 5-m walk test in 81.6%).
I
Intervention
Transcatheter aortic valve replacement (TAVR)
C
Comparator
Temporal trends (2012-2013 vs. 2014)
O
Outcome
Demographics, in-hospital procedural characteristics, and outcomessafety
Main Result
Absolute Event Rate: 4.2% vs 5.6%
The TVT Registry demonstrates that while TAVR patients remain elderly and high-risk, procedural techniques are evolving with decreasing vascular complications and increased use of percutaneous femoral access.
Cite This Study
Holmes et al. (2015) conducted an observational in Aortic valve disease requiring TAVR (n=26,414). Transcatheter aortic valve replacement (TAVR) in 2014 vs. TAVR in 2012-2013 was evaluated on Vascular complications. Transcatheter aortic valve replacement (TAVR) in the U.S. showed decreasing vascular complication rates (from 5.6% to 4.2%) and stable stroke rates (2.2%) between 2012-2013 and 2014.