Key result
Pregnancy in DCM with moderate/severe LV dysfunction linked to ~55% absolute reduction in event-free survival.
Why the study?
Women with dilated cardiomyopathy are at risk for complications during pregnancy, but few studies have examined outcomes in this specific population.
Does pregnancy increase the risk of adverse cardiac outcomes in women with dilated cardiomyopathy compared to nonpregnant women?
Population
36 pregnancies in 32 women with DCM and 18 matched nonpregnant women with DCM
Comparison
Pregnant women with DCM vs matched nonpregnant women with DCM
Design
Prospective cohort substudy and matched-pair analysis
Authors
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Cardiac events occurred more often in pregnant versus nonpregnant women with DCM; leaves open whether pregnancy accelerates disease progression.
Cohort (n=50)
Does pregnancy increase the risk of adverse cardiac outcomes in women with dilated cardiomyopathy compared to nonpregnant women?
Absolute Event Rate: 28% vs 83%
p-value: p=0.02
Pregnancy in women with dilated cardiomyopathy, particularly those with moderate/severe LV dysfunction or NYHA class III/IV, is associated with a significantly increased risk of adverse maternal cardiac events.
Grewal et al. (2009) conducted a cohort in Dilated cardiomyopathy (DCM) (n=50). Pregnancy vs. Nonpregnant women with DCM was evaluated on 16-month event-free survival in women with moderate/severe LV dysfunction (p=0.02). Pregnancy in women with dilated cardiomyopathy and moderate/severe LV dysfunction significantly worsened 16-month event-free survival compared to nonpregnant women (28% vs 83%, p=0.02).
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