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May 15, 2026Open Access

Emergence and spread of the XFG lineage in Brazil (2025-2026): gaps and challenges in genomic surveillance

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Authors

MSMarcella SenaEPElisa PereiraTSThauane Silva

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Overview

Descriptive study assesses XFG variant features in Brazil, revealing public health implications and monitoring needs.

Key Points

  • This study describes the genetic and clinical-epidemiological features of the SARS-CoV-2 XFG variant and its descendants in Brazil.
  • Descriptive study analyzing genomes from the EpiCoV platform on GISAID.
  • SARS-CoV-2 genomes classified using Pango-Nextclade.
  • Epidemiological data obtained from Brazilian health bulletins.
  • From March 2025 to January 2026, 71.33% of sequenced genomes were XFG variants (n=2,676).
  • XFG variant represented over 70% of sequenced genomes in Brazil from July to August 2025, with 55.36% global prevalence.
  • Significant vulnerability was noted in infants under 1 year, representing over 16% of XFG cases.

Cite This Study

Sena et al. (2026) studied this question.

synapsesocial.com/papers/6a06b74ce7dec685947aa389https://doi.org/10.35259/isi.2026_76288
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Also Consider

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  1. 1Genomic surveillance and vaccine response to the dominant SARS-CoV-2 XBB lineage in Rio Grande do Sul2024 · 2 citations
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  4. 4Analysis of the prevalence, spread, and mutation patterns of SARS-CoV-2 variants: data from COVID-19 testing expansion strategy study in salvador, Northeast Brazil2025
  5. 5Healthcare-facility-based SARS-CoV-2 genomic surveillance in Brazil: experience from the global action in healthcare network2026