Randomized trial examines genetic risk influence on neurocognitive outcomes in surgical patients, indicating potential for personalized care.
Key Points
This review aims to explore how preoperative genetic profiling, specifically APOE and Alzheimer’s disease polygenic risk scores, can aid in predicting perioperative neurocognitive disorders.
Review of existing perioperative cohort studies focusing on genetic profiling
Analysis of the role of APOE genotype and Alzheimer’s disease polygenic risk scores
Assessment of biomarkers alongside genetic factors in risk stratification
Strong genetic association found at the APOE locus linked to delirium risk and Alzheimer’s disease
APOE-aware framework proposed for preoperative risk assessment
Integration of genetic data with cognitive and clinical parameters suggested for better prediction