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May 15, 2026Clinical and Experimental Dermatology0 citations

Genital ulcer associated with an uncommon viral infection

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IMI. MateiUniversité Paris CitéPSPierre SohierUniversité Paris CitéNFNathalie FranckUniversité Paris Cité

Key Points

  • To present a rare case of genital ulcers associated with adult T-cell leukemia/lymphoma due to HTLV-1.
  • Histopathological examination of the lesions was conducted.
  • Immunohistochemical profiling for CD30 was performed.
  • Clinical evaluation included assessment of eye conditions like scleritis and panuveitis.
  • Histopathology revealed angiocentric necrotic lymphocytic proliferation.
  • The case emphasizes unique clinical manifestations of HTLV-1 linked to localized lesions.
  • Diagnosis included concurrent eye conditions correlating with the viral infection.

Abstract

We present a case of adult T-cell leukemia/lymphoma that manifested as localized necrotic lesions on the penis in an octogenarian patient born in Iran. A diagnosis of scleritis and panuveitis of the right eye was made oncomitantly. Histopathological examination revealed an angiocentric and necrotic atypical lymphocytic proliferation with an immunohistochemical profile positive for CD30. This unique presentation highlights the importance for dermatologists of being familiar with the diverse clinical and epidemiological characteristics of HTLV-1 infection.

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Cite This Study

Matei et al. (2026) studied this question.

synapsesocial.com/papers/6a06b86ae7dec685947aadf7https://doi.org/10.1093/ced/llag203
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