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June 5, 2026Journal of HematopathologyOpen Access

From serologic uncertainty to diagnostic clarity in unusual adult T-cell leukemia/lymphoma via HBZ in situ hybridization

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Authors

JCJorge Cheverez-OcasioUniversity of MinnesotaLML. Jeffrey MedeirosThe University of Texas MD Anderson Cancer CenterMTMehrnoosh TashakoriThe University of Texas MD Anderson Cancer Center

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Implication

Case report finds diagnostic value of HBZ ISH in ambiguous adult T-cell lymphoma, emphasizing HTLV-1 testing.

Key Points

  • To clarify diagnostic challenges in adult T-cell leukemia/lymphoma (ATLL) with atypical presentations.
  • Described a case of a 61-year-old man with aggressive CD4/CD8 double-positive T-cell lymphoma.
  • Performed HTLV serology and confirmed results with western blot.
  • Utilized HBZ in situ hybridization (ISH) to strengthen the diagnosis of ATLL.
  • Diagnosis of ATLL confirmed using HBZ ISH after atypical initial presentation.
  • Patient exhibited aggressive T-cell lymphoma with circulating lymphoma cells.
  • Emphasized the necessity of HTLV-1 serology in T-cell lymphoma diagnosis.

Cite This Study

Cheverez-Ocasio et al. (2026) studied this question.

synapsesocial.com/papers/6a22672f763171746d545ebbhttps://doi.org/10.1007/s12308-026-00705-6
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Also Consider

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