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November 1, 2025American Journal of Clinical PathologyOpen Access

274 Unexpected Morphology of Lymphomatous Adult T-cell Leukemia/Lymphoma in an Afro-Caribbean Patient

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Authors

HAHagar AttiaMHMary HannaEYElif Yakut

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Overview

Case report illustrates aggressive adult t-cell leukemia/lymphoma, revealing immunophenotype and diagnostic challenges.

Key Points

  • To highlight the diagnostic challenges associated with rare morphological features of adult T-cell leukemia/lymphoma (ATLL).
  • Case report of a 79-year-old Afro-Caribbean woman with ATLL
  • Biopsy and immunophenotyping to assess lymph node morphology
  • Testing for HTLV-1 serology and TCR gene-rearrangement
  • Patient exhibited pleomorphic medium to large cells with binucleated features
  • Diagnosis complicated by Hodgkin-like and anaplastic features
  • Patient died shortly after diagnosis, emphasizing the disease's aggressiveness

Cite This Study

Attia et al. (2025) studied this question.

synapsesocial.com/papers/69254371c0ce034ddc358843https://doi.org/10.1093/ajcp/aqaf121.247
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atypical Presentation for Adult T-Cell Leukemia/Lymphoma: a Case Report and Short Review of the Literature2024
  2. 2Lymphomatous-type adult T-cell leukemia/lymphoma associated with HTLV-1 presenting as chronic respiratory illness in a young adult: a case report2026
  3. 3Immunophenotypic, genetic, and clinical characterization of adult T-cell leukemia/lymphoma: A single tertiary care center experience in the United States2024 · 3 citations
  4. 4A review of cutaneous manifestations of HTLV-associated adult T-cell leukemia/lymphoma2025
  5. 5Acute Adult T-Cell Leukemia/Lymphoma Mimicking T-Cell Lymphoblastic Lymphoma in the Brazilian Amazon: A Case Report and Narrative Review of Latin American Cases2026